Interaction with biomolecules and biological activity of metal complexes and silver atomic quantum clusters
- Begoña García Ruiz Director
- Natalia Busto Vázquez Co-director
Defence university: Universidad de Burgos
Fecha de defensa: 26 June 2018
- José María Leal Villalba Chair
- Tomás Torroba Pérez Secretary
- Jorge González García Committee member
- Fernando Domínguez Puente Committee member
- José Ruiz López Committee member
Type: Thesis
Abstract
In this work the mechanisms of biological action of different drugs with potential anticancer activity are explored. These studies constitute the first steps in the basic research against cancer, as they aim at understanding the key factors that determine the biological activity of these drugs. This information on the structure-activity relationship helps to develop a rational design of new drugs with improved efficacy that could let us overcome problems such as the severe side effects of classical antitumor agents and the acquired resistance to these treatments.