Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies

  1. Broce, I. 1
  2. Karch, C.M. 2
  3. Wen, N. 2
  4. Fan, C.C. 3
  5. Wang, Y. 45
  6. Hong Tan, C. 1
  7. Kouri, N. 6
  8. Ross, O.A. 6
  9. Höglinger, G.U. 789
  10. Muller, U. 10
  11. Hardy, J. 11
  12. Momeni, P. 12120
  13. Hess, C.P. 1
  14. Dillon, W.P. 1
  15. Miller, Z.A. 1
  16. Bonham, L.W. 1
  17. Rabinovici, G.D. 1
  18. Rosen, H.J. 1
  19. Schellenberg, G.D. 13
  20. Franke, A. 14
  21. Karlsen, T.H. 151516
  22. Veldink, J.H. 17
  23. Ferrari, R. 11
  24. Yokoyama, J.S. 1
  25. Miller, B.L. 1
  26. Andreassen, O.A. 45
  27. Dale, A.M. 31819
  28. Desikan, R.S. 11
  29. Sugrue, L.P. 1
  30. Ferrari, R. 20
  31. Hernandez, D.G. 2122
  32. Nalls, M.A. 21
  33. Rohrer, J.D. 2324
  34. Ramasamy, A. 222526
  35. Kwok, J.B.J. 2728
  36. Dobson-Stone, C. 27
  37. Brooks, W.S. 2729
  38. Schofield, P.R. 2728
  39. Halliday, G.M. 2728
  40. Hodges, J.R. 2728
  41. Piguet, O. 2728
  42. Bartley, L. 27
  43. Thompson, E. 3031
  44. Haan, E. 3031
  45. Hernández, I. 32
  46. Ruiz, A. 32
  47. Boada, M. 32
  48. Borroni, B. 33
  49. Padovani, A. 33
  50. Cruchaga, C. 234
  51. Cairns, N.J. 234
  52. Benussi, L. 35
  53. Binetti, G. 36
  54. Ghidoni, R. 37
  55. Forloni, G. 38
  56. Albani, D. 38
  57. Galimberti, D. 3940
  58. Fenoglio, C. 3940
  59. Serpente, M. 3940
  60. Scarpini, E. 3940
  61. Clarimón, J. 4142
  62. Lleó, A. 4142
  63. Blesa, R. 4142
  64. Landqvist Waldö, M. 43
  65. Nilsson, K. 43
  66. Nilsson, C. 43
  67. Mackenzie, I.R.A. 44
  68. Hsiung, G.-Y.R. 44
  69. Mann, D.M.A. 45
  70. Grafman, J. 464748
  71. Morris, C.M. 494950
  72. Attems, J. 49
  73. Griffiths, T.D. 50
  74. G McKeith, I. 49
  75. Thomas, A.J. 49
  76. Pietrini, P. 51
  77. Huey, E.D. 52
  78. Wassermann, E.M. 53
  79. Baborie, A. 54
  80. Jaros, E. 55
  81. Tierney, M.C. 53
  82. Pastor, P. 425657
  83. Razquin, C. 56
  84. Ortega-Cubero, S. 4256
  85. Alonso, E. 56
  86. Perneczky, R. 75859
  87. Diehl-Schmid, J. 7
  88. Alexopoulos, P. 7
  89. Kurz, A. 7
  90. Rainero, I. 6061
  91. Rubino, E. 6061
  92. Pinessi, L. 6061
  93. Rogaeva, E. 62
  94. St George-Hyslop, P. 6364
  95. Rossi, G. 65
  96. Tagliavini, F. 65
  97. Giaccone, G. 65
  98. Rowe, J.B. 666768
  99. Schlachetzki, J.C.M. 69
  100. Uphill, J. 70
  101. Collinge, J. 70
  102. Mead, S. 70
  103. Danek, A. 7172
  104. Van Deerlin, V.M. 73
  105. Grossman, M. 74
  106. Trojanowski, J.Q. 73
  107. van der Zee, J. 7576
  108. Cruts, M. 7576
  109. Broeckhoven, C.V. 7576
  110. Cappa, S.F. 77
  111. Leber, I. 78798081
  112. Hannequin, D. 82
  113. Golfier, V. 83
  114. Vercelletto, M. 84
  115. Brice, A. 78798081
  116. Nacmias, B. 85
  117. Sorbi, S. 85
  118. Bagnoli, S. 85
  119. Piaceri, I. 85
  120. Nielsen, J.E. 8687
  121. Hjermind, L.E. 8687
  122. Riemenschneider, M. 8889
  123. Mayhaus, M. 89
  124. Ibach, B. 90
  125. Gasparoni, G. 89
  126. Pichler, S. 89
  127. Gu, W. 8991
  128. Rossor, M.N. 92
  129. Fox, N.C. 93
  130. Warren, J.D. 92
  131. Spillantini, M.G. 94
  132. Morris, H.R. 20
  133. Rizzu, P. 95
  134. Heutink, P. 95
  135. Snowden, J.S. 96
  136. Rollinson, S. 96
  137. Richardson, A. 97
  138. Gerhard, A. 98
  139. Bruni, A.C. 99
  140. Maletta, R. 99
  141. Frangipane, F. 99
  142. Cupidi, C. 99
  143. Bernardi, L. 99
  144. Anfossi, M. 99
  145. Gallo, M. 99
  146. Conidi, M.E. 99
  147. Smirne, N. 99
  148. Rademakers, R. 100
  149. Baker, M. 100
  150. Dickson, D.W. 100
  151. Graff-Radford, N.R. 101
  152. Petersen, R.C. 102
  153. Knopman, D. 102
  154. Josephs, K.A. 102
  155. Boeve, B.F. 102
  156. Parisi, J.E. 103
  157. Seeley, W.W. 1
  158. Miller, B.L. 1
  159. Karydas, A.M. 1
  160. Rosen, H. 1
  161. van Swieten, J.C. 104105
  162. Dopper, E.G.P. 104
  163. Seelaar, H. 104
  164. Pijnenburg, Y.A.L. 105
  165. Scheltens, P. 105
  166. Logroscino, G. 106
  167. Capozzo, R. 106
  168. Novelli, V. 107
  169. Puca, A.A. 108109
  170. Franceschi, M. 110
  171. Postiglione, A. 111
  172. Milan, G. 112
  173. Sorrentino, P. 112
  174. Kristiansen, M. 113
  175. Chiang, H.-H. 114115
  176. Graff, C. 114115
  177. Pasquier, F. 116
  178. Rollin, A. 116
  179. Deramecourt, V. 116
  180. Lebouvier, T. 116
  181. Kapogiannis, D. 117
  182. Ferrucci, L. 118
  183. Pickering-Brown, S. 96
  184. Singleton, A.B. 119
  185. Hardy, J. 20
  186. Show all authors +
  1. 1 University of California, San Francisco
    info

    University of California, San Francisco

    San Francisco, Estados Unidos

    ROR https://ror.org/043mz5j54

  2. 2 Washington University in St. Louis
    info

    Washington University in St. Louis

    San Luis, Estados Unidos

    ROR https://ror.org/01yc7t268

  3. 3 Department of Cognitive Sciences, University of California, San Diego
  4. 4 University of Oslo
    info

    University of Oslo

    Oslo, Noruega

    ROR https://ror.org/01xtthb56

  5. 5 Division of Mental Health and Addiction, Oslo University Hospital
  6. 6 Department of Neuroscience, Mayo Clinic
  7. 7 Technical University Munich
    info

    Technical University Munich

    Múnich, Alemania

    ROR https://ror.org/02kkvpp62

  8. 8 German Center for Neurodegenerative Diseases (DZNE)
  9. 9 Munich Cluster for Systems Neurology (SyNergy)
  10. 10 University of Giessen
    info

    University of Giessen

    Giessen, Alemania

    ROR https://ror.org/033eqas34

  11. 11 Department of Molecular Neuroscience, Institute of Neurology, University College London
  12. 12 Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Sciences Center
  13. 13 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania
  14. 14 Kiel University
    info

    Kiel University

    Kiel, Alemania

    ROR https://ror.org/04v76ef78

  15. 15 Oslo University Hospital
    info

    Oslo University Hospital

    Oslo, Noruega

    ROR https://ror.org/00j9c2840

  16. 16 University of Bergen
    info

    University of Bergen

    Bergen, Noruega

    ROR https://ror.org/03zga2b32

  17. 17 University Medical Center Utrecht
    info

    University Medical Center Utrecht

    Utrecht, Holanda

    ROR https://ror.org/0575yy874

  18. 18 University of California, San Diego
    info

    University of California, San Diego

    San Diego, Estados Unidos

    ROR https://ror.org/0168r3w48

  19. 19 Department of Neurosciences, University of California, San Diego
  20. 20 University College London
    info

    University College London

    Londres, Reino Unido

    ROR https://ror.org/02jx3x895

  21. 21 Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
  22. 22 Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology
  23. 23 Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology
  24. 24 Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology
  25. 25 Department of Medical and Molecular Genetics, King’s College London Tower Wing, Guy’s Hospital
  26. 26 University of Oxford
    info

    University of Oxford

    Oxford, Reino Unido

    ROR https://ror.org/052gg0110

  27. 27 Neuroscience Research Australia
    info

    Neuroscience Research Australia

    Sídney, Australia

    ROR https://ror.org/01g7s6g79

  28. 28 Commonwealth Scientific and Industrial Research Organisation
    info

    Commonwealth Scientific and Industrial Research Organisation

    Canberra, Australia

    ROR https://ror.org/03qn8fb07

  29. 29 Prince of Wales Clinical School, University of New South Wales
  30. 30 South Australian Clinical Genetics Service, SA Pathology (at Women's and Children's Hospital)
  31. 31 University of Adelaide
    info

    University of Adelaide

    Adelaida, Australia

    ROR https://ror.org/00892tw58

  32. 32 Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades
  33. 33 Università degli Studi di Brescia
    info

    Università degli Studi di Brescia

    Brescia, Italia

    ROR https://ror.org/02q2d2610

  34. 34 Washington University in St. Louis School of Medicine
    info

    Washington University in St. Louis School of Medicine

    San Luis, Estados Unidos

  35. 35 Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
  36. 36 MAC Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
  37. 37 Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli
  38. 38 Biology of Neurodegenerative Disorders, IRCCS Istituto di Ricerche Farmacologiche, “Mario Negri”
  39. 39 University of Milan
    info

    University of Milan

    Milán, Italia

    ROR https://ror.org/00wjc7c48

  40. 40 Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico
  41. 41 Universitat Autònoma de Barcelona
    info

    Universitat Autònoma de Barcelona

    Barcelona, España

    ROR https://ror.org/052g8jq94

  42. 42 Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
    info

    Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas

    Madrid, España

    ROR https://ror.org/00zca7903

  43. 43 Lund University
    info

    Lund University

    Lund, Suecia

    ROR https://ror.org/012a77v79

  44. 44 University of British Columbia
    info

    University of British Columbia

    Vancouver, Canadá

    ROR https://ror.org/03rmrcq20

  45. 45 Institute of Brain, Behaviour and Mental Health, University of Manchester, Salford Royal Hospital
  46. 46 Rehabilitation Institute of Chicago, Departments of Physical Medicine and Rehabilitation, Psychiatry, and Cognitive Neurology & Alzheimer's Disease Center
  47. 47 Feinberg School of Medicine, Northwestern University
  48. 48 Northwestern University
    info

    Northwestern University

    Evanston, Estados Unidos

    ROR https://ror.org/000e0be47

  49. 49 Newcastle University
    info

    Newcastle University

    Newcastle-upon-Tyne, Reino Unido

    ROR https://ror.org/01kj2bm70

  50. 50 Institute of Neuroscience, Newcastle University Medical School
  51. 51 IMT School for Advanced Studies, Lucca
  52. 52 Columbia University
    info

    Columbia University

    Nueva York, Estados Unidos

    ROR https://ror.org/00hj8s172

  53. 53 Behavioral Neurology Unit, National Insititute of Neurological Disorders and Stroke, National Insititutes of Health
  54. 54 Department of Laboratory Medicine & Pathology, Walter Mackenzie Health Sciences Centre, University of Alberta Edmonton
  55. 55 Newcastle University, Institute for Ageing and Health
  56. 56 Centro de Investigación Médica Aplicada
    info

    Centro de Investigación Médica Aplicada

    Pamplona, España

  57. 57 Universidad de Navarra
    info

    Universidad de Navarra

    Pamplona, España

    ROR https://ror.org/02rxc7m23

  58. 58 Imperial College London
    info

    Imperial College London

    Londres, Reino Unido

    ROR https://ror.org/041kmwe10

  59. 59 West London Cognitive Disorders Treatment and Research Unit, West London Mental Health Trust
  60. 60 University of Turin
    info

    University of Turin

    Turín, Italia

    ROR https://ror.org/048tbm396

  61. 61 A.O. Città della Salute e della Scienza di Torino
  62. 62 Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto
  63. 63 Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto
  64. 64 Cambridge Institute for Medical Research, and the Department of Clinical Neurosciences, University of Cambridge
  65. 65 Division of Neurology V and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta
  66. 66 Cambridge University Department of Clinical Neurosciences
  67. 67 MRC Cognition and Brain Sciences Unit
    info

    MRC Cognition and Brain Sciences Unit

    Cambridge, Reino Unido

    ROR https://ror.org/055bpw879

  68. 68 Behavioural and Clinical Neuroscience Institute
  69. 69 University of California San Diego, Department of Cellular & Molecular Medicine
  70. 70 MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology
  71. 71 Ludwig Maximilian University of Munich
    info

    Ludwig Maximilian University of Munich

    Múnich, Alemania

    ROR https://ror.org/05591te55

  72. 72 German Center for Neurodegenerative Diseases (DZNE)
  73. 73 University of Pennsylvania Perelman School of Medicine, Department of Pathology and Laboratory Medicine
  74. 74 University of Pennsylvania Perelman School of Medicine, Department of Neurology and Penn Frontotemporal Degeneration Center
  75. 75 Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB
  76. 76 Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp
  77. 77 Neurorehabilitation Unit, Dept. Of Clinical Neuroscience, Vita-Salute University and San Raffaele Scientific Institute
  78. 78 French Institute of Health and Medical Research
    info

    French Institute of Health and Medical Research

    París, Francia

    ROR https://ror.org/02vjkv261

  79. 79 Pierre and Marie Curie University
    info

    Pierre and Marie Curie University

    París, Francia

  80. 80 CNRS UMR 7225
  81. 81 Pitié-Salpêtrière Hospital
    info

    Pitié-Salpêtrière Hospital

    París, Francia

    ROR https://ror.org/02mh9a093

  82. 82 Service de Neurologie, Inserm U1079, CNR-MAJ, Rouen University Hospital
  83. 83 Service de neurologie
  84. 84 Service de neurologie, CHU Nantes
  85. 85 University of Florence
    info

    University of Florence

    Florencia, Italia

    ROR https://ror.org/04jr1s763

  86. 86 Copenhagen University Hospital
    info

    Copenhagen University Hospital

    Copenhague, Dinamarca

    ROR https://ror.org/05bpbnx46

  87. 87 Department of Cellular and Molecular Medicine, Section of Neurogenetics, The Panum Institute, University of Copenhagen
  88. 88 Saarland University Hospital, Department for Psychiatry & Psychotherapy
  89. 89 Saarland University, Laboratory for Neurogenetics
  90. 90 University of Regensburg
    info

    University of Regensburg

    Ratisbona, Alemania

    ROR https://ror.org/01eezs655

  91. 91 Luxembourg Centre For Systems Biomedicine (LCSB), University of Luxembourg
  92. 92 Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology
  93. 93 Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology Queen Square
  94. 94 University of Cambridge, Department of Clinical Neurosciences, John Van Geest Brain Repair Centre, Forvie Site
  95. 95 German Center for Neurodegenerative Diseases-Tübingen
  96. 96 University of Manchester
    info

    University of Manchester

    Mánchester, Reino Unido

    ROR https://ror.org/027m9bs27

  97. 97 Salford Royal Foundation Trust, Faculty of Medical and Human Sciences, University of Manchester
  98. 98 Institute of Brain, Behaviour and Mental Health, The University of Manchester
  99. 99 Regional Neurogenetic Centre, ASPCZ
  100. 100 Department of Neuroscience, Mayo Clinic Jacksonville
  101. 101 Department of Neurology, Mayo Clinic Jacksonville
  102. 102 Department of Neurology, Mayo Clinic Rochester
  103. 103 Department of Pathology, Mayo Clinic Rochester
  104. 104 Erasmus University Medical Center
    info

    Erasmus University Medical Center

    Róterdam, Holanda

    ROR https://ror.org/018906e22

  105. 105 VU University Medical Center
    info

    VU University Medical Center

    Ámsterdam, Holanda

    ROR https://ror.org/00q6h8f30

  106. 106 University of Bari Aldo Moro
    info

    University of Bari Aldo Moro

    Bari, Italia

    ROR https://ror.org/027ynra39

  107. 107 Medical Genetics Unit, Fondazione Policlinico Universitario A. Gemelli
  108. 108 Cardiovascular Research Unit, IRCCS Multimedica
  109. 109 Department of Medicine and Surgery, University of Salerno
  110. 110 Neurology Dept, IRCCS Multimedica
  111. 111 University of Naples Federico II
    info

    University of Naples Federico II

    Nápoles, Italia

    ROR https://ror.org/05290cv24

  112. 112 Geriatric Center Frullone- ASL Napoli 1 Centro
  113. 113 UCL Genomics, Institute of Child Health (ICH), UCL
  114. 114 Karolinska Institute
    info

    Karolinska Institute

    Estocolmo, Suecia

    ROR https://ror.org/056d84691

  115. 115 Karolinska University Hospital
    info

    Karolinska University Hospital

    Estocolmo, Suecia

    ROR https://ror.org/00m8d6786

  116. 116 Univ Lille, Inserm 1171, DISTALZ
  117. 117 National Institute on Aging (NIA/NIH)
  118. 118 Clinical Research Branch, National Institute on Aging
  119. 119 Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
  120. 120 Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Science Center
Journal:
PLoS Medicine

ISSN: 1549-1676

Year of publication: 2018

Volume: 15

Issue: 1

Type: Article

DOI: 10.1371/JOURNAL.PMED.1002487 PMID: 29315334 SCOPUS: 2-s2.0-85041689945 GOOGLE SCHOLAR lock_openOpen access editor
Data source: Scopus