The V471A Polymorphism in Autophagy-Related Gene ATG7 Modifies Age at Onset Specifically in Italian Huntington Disease Patients

Metzger, S.; Walter, C.; Riess, O.; Roos, R.A.C.; Nielsen, J.E.; Craufurd, D.; Nguyen, H.P.; Laccone, F.; Didonato, S.; Gellera, C.; Lange, H.W.; Weirich-Schwaiger, H.; Melegh, B.; Epplen, J.T.; Zaremba, J.; Basak, A.N.; Zidovska, J.; Pandolfo, M.; Kadasi, L.; Kvasnicova, M.; Weber, B.H.F.; Kreuz, F.; Dose, M.; Stuhrmann, M.; Bachoud-Lévi, A.-C.; Bentivoglio, A.R.; Biunno, I.; Bonelli, R.M.; Burgunder, J.-M.; Dunnett, S.B.; Ferreira, J.J.; Handley, O.J.; Heiberg, A.; Illmann, T.; Bernhard Landwehrmeyer, G.; Levey, J.; Ramos-Arroyo, M.A.; Nielsen, J.; Koivisto, S.P.; Päivärinta, M.; Sebastián, A.R.; Tabrizi, S.; Vandenberghe, W.; Verellen-Dumoulin, C.; Zaremba, J.; Uhrová, T.; Wahlström, J.; Barth, K.; Correia-Guedes, L.; Finisterra, A.M.; Garde, M.B.; Bos, R.; Betz, S.; Callaghan, J.; Fullam, R.; Ecker, D.; Nielsen, M.G.; Hvalstedt, C.; Held, C.; Koppers, K.; Laurà, M.; Horta, S.M.; Mestre, T.; Minster, S.; Monza, D.; Mütze, L.; Oehmen, M.; Townhill, J.; Orth, M.; Padieu, H.; Paterski, L.; Peppa, N.; Roedig, V.; Rialland, A.; Røren, N.; Šašinková, P.; Seliverstov, Y.; Cubillo, P.T.; van Walsem, M.R.; Wright, A.; da Silva, W.V.; Witjes-Ané, M.-N.; Yudina, E.; Zielonka, D.; Zielonka, E.; Zinzi, P.; Herranhof, B.; Holl, A.; Kapfhammer, H.-P.; Koppitz, M.; Magnet, M.; Otti, D.; Painold, A.; Reisinger, K.; Scheibl, M.; Hecht, K.; Lilek, S.; Müller, N.; Schöggl, H.; Ullah, J.; Ribaï, P.; Boogaerts, A.; van Reijen, D.; Klempír, J.; Majerová, V.; Roth, J.; Hjermind, L.; Jacobsen, O.; Vinthev-Jensen, T.; Larsen, I.U.; Stockholm, J.; Hiivola, H.; Martikainen, K.; Tuuha, K.; Ignatius, J.; Kärppä, M.; Åman, J.; Mustonen, A.; Kajula, O.; Santala, M.; Allain, P.; Guérid, M.-A.; Gohier, B.; Olivier, A.; Prundean, A.; Scherer-Gagou, C.; Verny, C.; Bost, M.; Babiloni, B.; Debruxelles, S.; Duché, C.; Goizet, C.; Lafoucrière, D.; Jameau, L.; Spampinato, U.; De Bruycker, C.; Cabaret, M.; Carette, A.-S.; Defebvre, L.; Decorte, E.; Delval, A.; Delliaux, M.; Destee, A.; Dujardin, K.; Peter, M.; Plomhouse, L.; Sablonnière, B.; Simonin, C.; Lemaire, M.-H.; Manouvrier, S.; Thibault-Tanchou, S.; Vuillaume, I.; Krystkowiak, P.; Duru, C.; Roussel, M.; Wannepain, S.; Berrissoul, H.; Bellonet, M.; Courtin, F.; Mantaux, B.; Fasquel, V.; Godefroy, O.; Azulay, J.-P.; Fluchère, F.; Delfini, M.; Eusebio, A.; Mundler, L.; Longato, N.; Rudolf, G.; Steinmetz, G.; Tranchant, C.; Wagner, C.; Zimmermann, M.-A.; Marcel, C.; Andrich, J.; Ellrichmann, G.; Hoffmann, R.; Kaminski, B.; Saft, C.; Stamm, C.; Boelmans, K.; Ganos, C.; Goerendt, I.; Hidding, U.; Lewerenz, J.; Münchau, A.; Schmalfeld, J.; Stubbe, L.; Zittel, S.; Bürk, K.; Möller, J.C.; Rissling, I.; Cormio, C.; Sciruicchio, V.; Serpino, C.; de Tommaso, M.; Capellari, S.; Cortelli, P.; Gallassi, R.; Poda, R.; Rizzo, G.; Scaglione, C.; Abbruzzese, G.; di Poggio, M.B.; Di Maria, E.; Ferrandes, G.; Mandich, P.; Marchese, R.; Albanese, A.; Di Bella, D.; Di Donato, S.; Gellera, C.; Genitrini, S.; Mariotti, C.; Nanetti, L.; Paridi, D.; Soliveri, P.; Tomasello, C.; Squitieri, F.; Elifani, F.; Maglione, V.; Di Pardo, A.; Alberti, S.; Griguoli, A.; Amico, E.; Martino, T.; Petrollini, M.; Catalli, C.; Di Giacopo, R.; Fasano, A.; Frontali, M.; Guidubaldi, A.; Ialongo, T.; Jacopini, G.; Loria, G.; Piano, C.; Chiara, P.; Quaranta, D.; Romano, S.; Soleti, F.; Spadaro, M.; van Hout, M.S.E.; van Vugt, J.P.P.; de Weert, A.M.; Bolwijn, J.J.W.; Dekker, M.; Leenders, K.L.; Kremer, H.P.H.; Dumas, E.M.; van den Bogaard, S.J.A.; 't Hart, E.P.; van Duijn, E.; Kremer, B.; Verstappen, C.C.P.; Blinkenberg, E.Ø.; Hauge, E.; Tyvoll, H.; Frich, J.; Aaserud, O.; Wehus, R.; Bjørgo, K.; Fannemel, M.; Gørvell, P.; Lorentzen, E.; Retterstøl, L.; Overland, T.; Stokke, B.; Bjørnevoll, I.; Sando, S.B.; Dziadkiewicz, A.; Nowak, M.; Robowski, P.; Sitek, E.; Slawek, J.; Soltan, W.; Szinwelski, M.; Blaszcyk, M.; Boczarska-Jedynak, M.; Ciach-Wysocka, E.; Gorzkowska, A.; Jasinska-Myga, B.; Opala, G.; Klodowska-Duda, G.; Stompel, D.; Banaszkiewicz, K.; Bocwinska, D.; Szczudlik, A.; Rudzinska, M.; Wójcik, M.; Dec, M.; Krawczyk, M.; Bojakowska-Jaremek, K.; Szczygiel, E.; Stenwak, A.; Wasielewska, A.; Bryl, A.; Ciesielska, A.; Klimberg, A.; Marcinkowski, J.; Sempolowicz, J.; Samara, H.; Wisniewski, B.; Janik, P.; Gogol, A.; Kwiecinski, H.; Jamrozik, Z.; Kaminska, A.; Antczak, J.; Jachinska, K.; Rakowicz, M.; Richter, P.; Rola, R.; Ryglewicz, D.; Sienkiewicz-Jarosz, H.; Stepniak, I.; Witkowski, G.; Zdzienicka, E.; Sulek, A.; Krysa, W.; Zieora-Jakutowicz, K.; Júlio, F.; Januário, C.; Coelho, M.; Mendes, T.; Valadas, A.; Ferreira, J.J.; Andrade, C.; Gago, M.; Garrett, C.; Guerra, M.R.; Lima, J.; Massano, J.; Meireles, J.; Herrera, C.D.; Garcia, P.M.; Barrero, F.; Morales, B.; Cubo, E.; Mariscal, N.; Sánchez, J.; Alonso-Frech, F.; Perez, M.R.; Fenollar, M.; García, R.G.-R.; Quiroga, P.P.; Rivera, S.V.; Villanueva, C.; Alegre, J.; Bascuñana, M.; Caldentey, J.G.; Ventura, M.F.; Ribas, G.G.; de Yébenes, J.G.; López-Sendón Moreno, J.L.; García Ruíz, P.J.; Martínez-Descals, A.; Artiga, M.J.S.; Sánchez, V.; Guerrero, R.; Bárcenas, A.H.; Perea, M.F.N.; Fortuna, L.; Torres, M.M.A.; Reinante, G.; Moreau, L.V.; Barbera, M.A.; Guia, D.B.; Hernanz, L.C.; Catena, J.L.; Ferrer, P.Q.; Carruesco, G.T.; Bas, J.; Busquets, N.; Calopa, M.; Elorza, M.D.; Díez-Aja López, C.; Durán-Sindreu Terol, S.; Robert, M.F.; Ruíz, B.G.; Casado, A.G.; Martínez, I.H.; Viladrich, C.M.; Pons i Càrdenas, R.; Roca, E.; Llesoy, J.R.; Idiago, J.M.R.; Vergara, M.R.; García, S.S.; Riballo, A.V.; González, S.G.; Guisasola, L.M.; Salvador, C.; Martín, E.S.S.; González, M.; Gorospe, A.; Legarda, I.; Arques, P.N.; Rodríguez, M.J.T.; Vives, B.; Gaston, I.; Martinez-Jaurrieta, M.D.; Moreno, J.M.G.; Pen˜a, J.C.; Avarvarei, L.D.; Bastida, A.M.; Recio, M.F.; Vergé, L.R.; Sánchez, V.S.; Carrillo, F.; Cáceres, M.T.; Mir, P.; Suarez, M.J.L.; Loutfi, G.; Olofsson, C.; Stattin, E.-L.; Westman, L.; Wikström, B.; Pålhagen, S.E.; Paucar, M.; Svenningsson, P.; Reza-Soltani, T.W.; Höglund, A.; Sandström, B.; Høsterey-Ugander, U.; Fredlund, G.; Constantinescu, R.; Neleborn-Lingefjärd, L.; Stebler, Y.; Kaelin, A.; Romero, I.; Schüpbach, M.; Zaugg, S.W.; Miedzybrodzka, Z.; Rae, D.; Downie, L.; Simpson, S.; Summers, F.; Ure, A.; Jack, R.; Matheson, K.; Akhtar, S.; Crooks, J.; Curtis, A.; de Souza (Keylock), J.; Rickards, H.; Wright, J.; Barker, R.A.; O'Keefe, D.; Di Pietro, A.; Fisher, K.; Goodman, A.; Hill, S.; Mason, S.; Swain, R.; Guzman, N.V.; Bisson, J.; Busse, M.; Butcher, C.; Clenaghan, C.; Dunnett, S.; Handley, O.; Hunt, S.; Hughes, A.; Johnstone, C.; Jones, L.; Jones, U.; Khalil, H.; Owen, M.; Price, K.; Rose, L.E.; Rosser, A.; Porteous, M.; Edwards, M.; Ho, C.; McGill, M.; Pearson, P.; Brockie, P.; Foster, J.; Johns, N.; McKenzie, S.; Rothery, J.; Thomas, G.; Yates, S.; Burrows, L.; Fletcher, A.; Harding, A.; Laver, F.; Silva, M.; Thomson, A.; Rowett, L.; Gallantrae, D.; Longthorpe, M.; Markova, I.; Raman, A.; Hamer, S.; Wild, S.; Yarduiman, P.; Chu, C.; Kraus, A.; Yardumian, P.; Musgrave, H.; Toscano, J.; Jamieson, S.; Hobson, E.; Clayton, C.; Dipple, H.; Middleton, J.; Freire-Patino, D.; Andrews, T.; Dougherty, A.; Kavalier, F.; Golding, C.; Laing, H.; Lashwood, A.; Robertson, D.; Ruddy, D.; Whaite, A.; Santhouse, A.; Patton, M.; Peterson, M.; Rose, S.; Bruno, S.; Chu, E.; Doherty, K.; Haider, S.; Hensman, D.; Lahiri, N.; Lewis, M.; Novak, M.; Patel, A.; Robertson, N.; Rosser, E.; Taylor, R.; Warner, T.; Wild, E.; Craufurd, D.; Howard, L.; Sollom, A.; Snowden, J.; Thompson, J.; Jones, M.; Murphy, H.; Trender-Gerhard, I.; Rogers, D.; Bek, J.; Oughton, E.; Johnson, L.; Hare, M.; Arran, N.; Verstraelen, N.; Partington-Jones, L.; Huson, S.; Stopford, C.; Westmoreland, L.; Davidson, J.; Morgan, K.; Savage, L.; Singh, B.; Komati, S.; Nemeth, A.H.; Armstrong, R.; Valentine, R.; Siuda, G.; Harrison, D.; Hughes, M.; Parkinson, A.; Soltysiak, B.; Bandmann, O.; Bradbury, A.; Gill, P.; Fairtlough, H.; Fillingham, K.; Foustanos, I.; Kazoka, M.; O'Donovan, K.; Taylor, C.; Tidswell, K.; Quarrell, O.

doi:10.1371/JOURNAL.PONE.0068951

The V471A Polymorphism in Autophagy-Related Gene ATG7 Modifies Age at Onset Specifically in Italian Huntington Disease Patients

Metzger, S. ¹¹
Walter, C. ¹¹
Riess, O. ¹¹
Roos, R.A.C. ²²
Nielsen, J.E. ³⁴
Craufurd, D. ⁵
Nguyen, H.P. ¹¹
Laccone, F. ⁶
Didonato, S. ⁷
Gellera, C. ⁷
Lange, H.W. ⁸
Weirich-Schwaiger, H. ⁹
Melegh, B. ¹⁰
Epplen, J.T. ¹¹
Zaremba, J. ¹²
Basak, A.N. ¹³
Zidovska, J. ¹⁴
Pandolfo, M. ¹⁵
Kadasi, L. ¹⁶
Kvasnicova, M. ¹⁷
Weber, B.H.F. ¹⁸
Kreuz, F. ¹⁹
Dose, M. ²⁰
Stuhrmann, M. ²¹
Bachoud-Lévi, A.-C. ²²
Bentivoglio, A.R. ²³⁵⁴
Biunno, I. ²⁴
Bonelli, R.M. ²⁵⁵⁵
Burgunder, J.-M. ²⁶¹⁰³
Dunnett, S.B. ²⁷
Ferreira, J.J. ²⁸
Handley, O.J. ²⁷²⁷
Heiberg, A. ²⁹²⁹
Illmann, T. ³⁰
Bernhard Landwehrmeyer, G. ³¹
Levey, J. ³²
Ramos-Arroyo, M.A. ³³
Nielsen, J. ³
Koivisto, S.P. ³⁴
Päivärinta, M. ³⁵
Sebastián, A.R. ³⁶⁹⁴
Tabrizi, S. ³⁷
Vandenberghe, W. ³⁸³⁸
Verellen-Dumoulin, C. ³⁹
Zaremba, J. ⁴⁰
Uhrová, T. ⁴¹
Wahlström, J. ⁴²
Barth, K. ⁴³
Correia-Guedes, L. ²⁸
Finisterra, A.M. ⁴⁴
Garde, M.B. ⁴⁴
Bos, R. ²
Betz, S. ⁵
Callaghan, J. ²⁷
Fullam, R. ⁵²⁷
Ecker, D. ³¹
Nielsen, M.G.
Hvalstedt, C. ³¹
Held, C. ³¹
Koppers, K.
Laurà, M.
Horta, S.M.
Mestre, T. ²⁸
Minster, S. ²⁷
Monza, D. ⁴⁵
Mütze, L. ³¹
Oehmen, M. ⁴⁶
Townhill, J. ²⁷
Orth, M. ⁴⁷
Padieu, H.
Paterski, L.
Peppa, N. ⁴⁸
Roedig, V. ⁴⁹
Rialland, A. ⁴⁹
Røren, N. ²⁹
Šašinková, P.
Seliverstov, Y.
Cubillo, P.T. ⁴⁴
van Walsem, M.R. ²⁹
Wright, A. ²⁵⁰
da Silva, W.V. ²⁵⁰
Witjes-Ané, M.-N. ²⁵⁰
Yudina, E. ⁵¹
Zielonka, D. ⁵²
Zielonka, E. ⁵³
Zinzi, P. ⁵⁴
Herranhof, B. ⁵⁵
Holl, A. ⁵⁵
Kapfhammer, H.-P. ⁵⁵
Koppitz, M. ⁵⁵
Magnet, M. ⁵⁵
Otti, D. ⁵⁵
Painold, A. ⁵⁵
Reisinger, K. ⁵⁵
Scheibl, M. ⁵⁵
Hecht, K. ⁵⁵
Lilek, S. ⁵⁵
Müller, N. ⁵⁵
Schöggl, H. ⁵⁵
Ullah, J. ⁵⁵
Ribaï, P. ⁵⁶
Boogaerts, A. ³⁸
van Reijen, D. ³⁸
Klempír, J. ⁵⁷
Majerová, V. ⁵⁷
Roth, J. ⁵⁷
Hjermind, L. ³
Jacobsen, O. ³
Vinthev-Jensen, T. ³
Larsen, I.U. ³
Stockholm, J. ³
Hiivola, H. ⁵⁸
Martikainen, K. ⁵⁸
Tuuha, K. ⁵⁸
Ignatius, J. ⁵⁹
Kärppä, M. ⁵⁹
Åman, J. ⁵⁹
Mustonen, A. ⁵⁹
Kajula, O. ⁵⁹
Santala, M. ⁶⁰
Allain, P. ⁶¹
Guérid, M.-A. ⁶¹
Gohier, B. ⁶¹
Olivier, A. ⁶¹
Prundean, A. ⁶¹
Scherer-Gagou, C. ⁶¹
Verny, C. ⁶¹
Bost, M. ⁶¹
Babiloni, B. ⁶²
Debruxelles, S. ⁶²
Duché, C. ⁶²
Goizet, C. ⁶²
Lafoucrière, D. ⁶²
Jameau, L. ⁶²
Spampinato, U. ⁶²
De Bruycker, C. ⁶³
Cabaret, M. ⁶³
Carette, A.-S. ⁶³
Defebvre, L. ⁶³⁶³
Decorte, E. ⁶³
Delval, A. ⁶³
Delliaux, M. ⁶³
Destee, A. ⁶³
Dujardin, K. ⁶³
Peter, M. ⁶³
Plomhouse, L. ⁶³
Sablonnière, B. ⁶³
Simonin, C. ⁶³
Lemaire, M.-H. ⁶³
Manouvrier, S. ⁶³
Thibault-Tanchou, S. ⁶³
Vuillaume, I. ⁶³
Krystkowiak, P. ⁶⁴
Duru, C. ⁶⁴
Roussel, M. ⁶⁴
Wannepain, S. ⁶⁴
Berrissoul, H. ⁶⁴
Bellonet, M. ⁶⁴
Courtin, F. ⁶⁴
Mantaux, B. ⁶⁴
Fasquel, V. ⁶⁴
Godefroy, O. ⁶⁴
Azulay, J.-P. ⁶⁵
Fluchère, F. ⁶⁵
Delfini, M. ⁶⁵
Eusebio, A. ⁶⁵
Mundler, L. ⁶⁵
Longato, N. ⁶⁶
Rudolf, G. ⁶⁶
Steinmetz, G. ⁶⁶
Tranchant, C. ⁶⁶
Wagner, C. ⁶⁶
Zimmermann, M.-A. ⁶⁶
Marcel, C. ⁶⁶
Andrich, J. ⁶⁷
Ellrichmann, G. ⁶⁷
Hoffmann, R. ⁶⁷
Kaminski, B. ⁶⁷
Saft, C. ⁶⁷
Stamm, C. ⁶⁷
Boelmans, K. ⁴⁷
Ganos, C. ⁴⁷
Goerendt, I. ⁴⁷
Hidding, U. ⁴⁷
Lewerenz, J. ⁴⁷
Münchau, A. ⁴⁷
Schmalfeld, J. ⁴⁷
Stubbe, L. ⁴⁷
Zittel, S. ⁴⁷
Bürk, K. ⁶⁸
Möller, J.C. ⁶⁸
Rissling, I. ⁶⁸
Cormio, C. ⁶⁹
Sciruicchio, V. ⁶⁹
Serpino, C. ⁶⁹
de Tommaso, M. ⁶⁹
Capellari, S. ⁷⁰
Cortelli, P. ⁷⁰
Gallassi, R. ⁷⁰
Poda, R. ⁷⁰
Rizzo, G. ⁷⁰
Scaglione, C. ⁷⁰
Abbruzzese, G. ⁷¹⁷²
di Poggio, M.B. ⁷¹⁷²
Di Maria, E. ⁷¹⁷²
Ferrandes, G. ⁷¹⁷²
Mandich, P. ⁷¹⁷²
Marchese, R. ⁷¹⁷²
Albanese, A. ⁴⁵
Di Bella, D. ⁴⁵
Di Donato, S. ⁴⁵
Gellera, C. ⁴⁵
Genitrini, S. ⁴⁵
Mariotti, C. ⁴⁵
Nanetti, L. ⁴⁵
Paridi, D. ⁴⁵
Soliveri, P. ⁴⁵
Tomasello, C. ⁴⁵
Squitieri, F. ⁷³
Elifani, F. ⁷³
Maglione, V. ⁷³
Di Pardo, A. ⁷³
Alberti, S. ⁷³
Griguoli, A. ⁷³
Amico, E. ⁷³
Martino, T. ⁷³
Petrollini, M. ⁷⁴
Catalli, C. ⁵⁴
Di Giacopo, R. ⁵⁴
Fasano, A. ⁵⁴
Frontali, M. ⁵⁴
Guidubaldi, A. ⁵⁴
Ialongo, T. ⁵⁴
Jacopini, G. ⁵⁴
Loria, G. ⁵⁴
Piano, C. ⁵⁴
Chiara, P. ⁵⁴
Quaranta, D. ⁵⁴
Romano, S. ⁵⁴
Soleti, F. ⁵⁴
Spadaro, M. ⁵⁴
van Hout, M.S.E. ⁷⁵
van Vugt, J.P.P. ⁷⁵
de Weert, A.M. ⁷⁵
Bolwijn, J.J.W. ⁷⁶
Dekker, M. ⁷⁶
Leenders, K.L. ⁷⁶
Kremer, H.P.H. ⁷⁶
Dumas, E.M. ²
van den Bogaard, S.J.A. ²
't Hart, E.P. ²
van Duijn, E. ²
Kremer, B. ⁷⁷
Verstappen, C.C.P. ⁷⁷
Blinkenberg, E.Ø. ⁷⁸
Hauge, E. ⁷⁹
Tyvoll, H. ⁷⁹
Frich, J. ²⁹
Aaserud, O. ²⁹
Wehus, R. ²⁹
Bjørgo, K. ³⁴
Fannemel, M. ³⁴
Gørvell, P. ³⁴
Lorentzen, E. ³⁴
Retterstøl, L. ³⁴
Overland, T. ³⁴
Stokke, B. ³⁴
Bjørnevoll, I. ⁸⁰
Sando, S.B. ⁸⁰
Dziadkiewicz, A. ⁸¹
Nowak, M. ⁸¹
Robowski, P. ⁸¹
Sitek, E. ⁸¹
Slawek, J. ⁸¹
Soltan, W. ⁸¹
Szinwelski, M. ⁸¹
Blaszcyk, M. ⁸²
Boczarska-Jedynak, M. ⁸²
Ciach-Wysocka, E. ⁸²
Gorzkowska, A. ⁸²
Jasinska-Myga, B. ⁸²
Opala, G. ⁸²
Klodowska-Duda, G. ⁸²
Stompel, D. ⁸²
Banaszkiewicz, K. ⁸³
Bocwinska, D. ⁸³
Szczudlik, A. ⁸³
Rudzinska, M. ⁸³
Wójcik, M. ⁸³
Dec, M. ⁸³
Krawczyk, M. ⁸³
Bojakowska-Jaremek, K. ⁸³
Szczygiel, E. ⁸³
Stenwak, A. ⁸³
Wasielewska, A. ⁸³
Bryl, A. ⁵²
Ciesielska, A. ⁵²
Klimberg, A. ⁵²
Marcinkowski, J. ⁵²
Sempolowicz, J. ⁵²
Samara, H. ⁵²
Wisniewski, B. ⁵²
Janik, P. ⁸⁴
Gogol, A. ⁸⁴
Kwiecinski, H. ⁸⁴
Jamrozik, Z. ⁸⁴
Kaminska, A. ⁸⁴
Antczak, J. ⁴⁰
Jachinska, K. ⁴⁰
Rakowicz, M. ⁴⁰
Richter, P. ⁴⁰
Rola, R. ⁴⁰
Ryglewicz, D. ⁴⁰
Sienkiewicz-Jarosz, H. ⁴⁰
Stepniak, I. ⁴⁰⁴⁰
Witkowski, G. ⁴⁰
Zdzienicka, E. ⁴⁰
Sulek, A. ⁴⁰
Krysa, W. ⁴⁰
Zieora-Jakutowicz, K. ⁴⁰
Júlio, F. ⁸⁵
Januário, C. ⁸⁵
Coelho, M. ²⁸
Mendes, T. ²⁸
Valadas, A. ²⁸
Ferreira, J.J. ²⁸
Andrade, C. ⁸⁶
Gago, M. ⁸⁶
Garrett, C. ⁸⁶
Guerra, M.R. ⁸⁶
Lima, J. ⁸⁶
Massano, J. ⁸⁶
Meireles, J. ⁸⁶
Herrera, C.D. ⁸⁷
Garcia, P.M. ⁸⁷
Barrero, F. ⁸⁸
Morales, B. ⁸⁸
Cubo, E. ⁸⁹
Mariscal, N. ⁸⁹
Sánchez, J. ⁸⁹
Alonso-Frech, F. ⁹⁰
Perez, M.R. ⁹⁰
Fenollar, M. ⁹¹
García, R.G.-R. ⁹¹
Quiroga, P.P. ⁹¹
Rivera, S.V. ⁹¹
Villanueva, C. ⁹¹
Alegre, J. ⁴⁴
Bascuñana, M. ⁴⁴
Caldentey, J.G. ⁴⁴
Ventura, M.F. ⁴⁴
Ribas, G.G. ⁴⁴
de Yébenes, J.G. ⁴⁴
López-Sendón Moreno, J.L. ⁴⁴
García Ruíz, P.J. ⁹²
Martínez-Descals, A. ⁹²
Artiga, M.J.S. ⁹²
Sánchez, V. ⁹²
Guerrero, R. ⁹²
Bárcenas, A.H. ⁹²
Perea, M.F.N. ⁹³
Fortuna, L. ⁹³
Torres, M.M.A. ⁹³
Reinante, G. ⁹³
Moreau, L.V. ⁹³
Barbera, M.A. ⁹⁴
Guia, D.B. ⁹⁴
Hernanz, L.C. ⁹⁴
Catena, J.L. ⁹⁴
Ferrer, P.Q. ⁹⁴
Carruesco, G.T. ⁹⁴
Bas, J. ⁹⁵
Busquets, N. ⁹⁵
Calopa, M. ⁹⁵
Elorza, M.D. ⁹⁶
Díez-Aja López, C. ⁹⁶
Durán-Sindreu Terol, S. ⁹⁶
Robert, M.F. ⁹⁶
Ruíz, B.G. ⁹⁶
Casado, A.G. ⁹⁶
Martínez, I.H. ⁹⁶
Viladrich, C.M. ⁹⁶
Pons i Càrdenas, R. ⁹⁶
Roca, E. ⁹⁶
Llesoy, J.R. ⁹⁶
Idiago, J.M.R. ⁹⁶
Vergara, M.R. ⁹⁶
García, S.S. ⁹⁶
Riballo, A.V. ⁹⁶
González, S.G. ⁹⁷
Guisasola, L.M. ⁹⁷
Salvador, C. ⁹⁷
Martín, E.S.S. ⁹⁷
González, M. ⁹⁸
Gorospe, A. ⁹⁸
Legarda, I. ⁹⁸
Arques, P.N. ⁹⁸
Rodríguez, M.J.T. ⁹⁸
Vives, B. ⁹⁸
Gaston, I. ³³
Martinez-Jaurrieta, M.D. ³³
Moreno, J.M.G. ⁹⁹
Pen˜a, J.C. ⁹⁹
Avarvarei, L.D. ⁹⁹
Bastida, A.M. ⁹⁹
Recio, M.F. ⁹⁹
Vergé, L.R. ⁹⁹
Sánchez, V.S. ⁹⁹
Carrillo, F. ¹⁰⁰
Cáceres, M.T. ¹⁰⁰
Mir, P. ¹⁰⁰
Suarez, M.J.L. ¹⁰⁰
Loutfi, G. ¹⁰¹
Olofsson, C. ¹⁰¹
Stattin, E.-L. ¹⁰¹
Westman, L. ¹⁰¹
Wikström, B. ¹⁰¹
Pålhagen, S.E. ¹⁰²
Paucar, M. ¹⁰²
Svenningsson, P. ¹⁰²
Reza-Soltani, T.W. ¹⁰²
Höglund, A. ¹⁰²
Sandström, B. ¹⁰²
Høsterey-Ugander, U. ⁴²
Fredlund, G. ⁴²
Constantinescu, R. ⁴²
Neleborn-Lingefjärd, L. ⁴²
Stebler, Y. ¹⁰³
Kaelin, A. ²⁶
Romero, I. ²⁶
Schüpbach, M. ²⁶
Zaugg, S.W. ²⁶
Miedzybrodzka, Z. ¹⁰⁴
Rae, D. ¹⁰⁴
Downie, L. ¹⁰⁴
Simpson, S. ¹⁰⁴
Summers, F. ¹⁰⁴
Ure, A. ¹⁰⁴
Jack, R. ¹⁰⁴
Matheson, K. ¹⁰⁴
Akhtar, S. ¹⁰⁵
Crooks, J. ¹⁰⁵
Curtis, A. ¹⁰⁵
de Souza (Keylock), J. ¹⁰⁵
Rickards, H. ¹⁰⁵
Wright, J. ¹⁰⁵
Barker, R.A. ¹⁰⁶
O'Keefe, D. ¹⁰⁶
Di Pietro, A. ¹⁰⁶
Fisher, K. ¹⁰⁶
Goodman, A. ¹⁰⁶
Hill, S. ¹⁰⁶
Mason, S. ¹⁰⁶
Swain, R. ¹⁰⁶
Guzman, N.V. ¹⁰⁶
Bisson, J. ²⁷
Busse, M. ²⁷
Butcher, C. ²⁷
Clenaghan, C. ²⁷
Dunnett, S. ²⁷
Handley, O. ²⁷
Hunt, S. ²⁷
Hughes, A. ²⁷
Johnstone, C. ²⁷
Jones, L. ²⁷
Jones, U. ²⁷
Khalil, H. ²⁷
Owen, M. ²⁷
Price, K. ²⁷
Rose, L.E. ²⁷
Rosser, A. ²⁷
Porteous, M. ¹⁰⁷
Edwards, M. ¹⁰⁷
Ho, C. ¹⁰⁷
McGill, M. ¹⁰⁷
Pearson, P. ¹⁰⁷
Brockie, P. ¹⁰⁸
Foster, J. ¹⁰⁸
Johns, N. ¹⁰⁸
McKenzie, S. ¹⁰⁸
Rothery, J. ¹⁰⁸
Thomas, G. ¹⁰⁸
Yates, S. ¹⁰⁸
Burrows, L. ¹⁰⁹
Fletcher, A. ¹⁰⁹
Harding, A. ¹⁰⁹
Laver, F. ¹⁰⁹
Silva, M. ¹⁰⁹
Thomson, A. ¹⁰⁹
Rowett, L. ¹¹⁰¹¹¹
Gallantrae, D. ¹¹⁰
Longthorpe, M. ¹¹⁰
Markova, I. ¹¹⁰
Raman, A. ¹¹⁰
Hamer, S. ¹¹⁰
Wild, S. ¹¹⁰¹¹¹
Yarduiman, P. ¹¹⁰
Chu, C. ¹¹⁰
Kraus, A. ¹¹⁰
Yardumian, P. ¹¹¹
Musgrave, H. ¹¹¹
Toscano, J. ¹¹¹
Jamieson, S. ¹¹¹
Hobson, E. ¹¹¹
Clayton, C. ¹¹²
Dipple, H. ¹¹²
Middleton, J. ¹¹²
Freire-Patino, D. ¹¹²
Andrews, T. ³⁷¹¹³
Dougherty, A. ¹¹³
Kavalier, F. ¹¹³
Golding, C. ³⁷¹¹³
Laing, H. ¹¹³
Lashwood, A. ¹¹³
Robertson, D. ¹¹³
Ruddy, D. ¹¹³
Whaite, A. ¹¹³
Santhouse, A. ¹¹³
Patton, M. ¹¹⁴
Peterson, M. ¹¹⁴
Rose, S. ¹¹⁴
Bruno, S. ³⁷
Chu, E. ³⁷
Doherty, K. ³⁷
Haider, S. ³⁷
Hensman, D. ³⁷
Lahiri, N. ³⁷
Lewis, M. ³⁷
Novak, M. ³⁷
Patel, A. ³⁷
Robertson, N. ³⁷
Rosser, E. ³⁷
Taylor, R. ³⁷
Warner, T. ³⁷
Wild, E. ³⁷
Craufurd, D. ⁵
Howard, L. ⁵
Sollom, A. ⁵
Snowden, J. ⁵
Thompson, J. ⁵
Jones, M. ⁵
Murphy, H. ⁵
Trender-Gerhard, I. ⁵
Rogers, D. ⁵
Bek, J. ⁵
Oughton, E. ⁵
Johnson, L. ⁵
Hare, M. ⁵
Arran, N. ⁵
Verstraelen, N. ⁵
Partington-Jones, L. ⁵
Huson, S. ⁵
Stopford, C. ⁵
Westmoreland, L. ⁵
Davidson, J. ¹¹⁵
Morgan, K. ¹¹⁵
Savage, L. ¹¹⁵
Singh, B. ¹¹⁵
Komati, S. ¹¹⁵
Nemeth, A.H. ¹¹⁶
Armstrong, R. ¹¹⁶
Valentine, R. ¹¹⁶
Siuda, G. ¹¹⁶
Harrison, D. ¹¹⁷
Hughes, M. ¹¹⁷
Parkinson, A. ¹¹⁷
Soltysiak, B. ¹¹⁷
Bandmann, O. ⁴⁸
Bradbury, A. ⁴⁸
Gill, P. ⁴⁸
Fairtlough, H. ⁴⁸
Fillingham, K. ⁴⁸
Foustanos, I. ⁴⁸
Kazoka, M. ⁴⁸
O'Donovan, K. ⁴⁸
Taylor, C. ⁴⁸
Tidswell, K. ⁴⁸
Quarrell, O. ⁴⁸
Show all authors +

1 University of Tübingen

University of Tübingen

Tubinga, Alemania

ROR https://ror.org/03a1kwz48
2 Leiden University Medical Center

Leiden University Medical Center

Leiden, Holanda

ROR https://ror.org/05xvt9f17
3 Copenhagen University Hospital

Copenhagen University Hospital

Copenhague, Dinamarca

ROR https://ror.org/05bpbnx46
4 Institute of Cellular and Molecular Medicine, Section of Neurogenetics, University of Copenhagen, The Panum Institute
5 University of Manchester

University of Manchester

Mánchester, Reino Unido

ROR https://ror.org/027m9bs27
6 Department of Medical Genetics
7 National Institute of Neurology Carlo Besta
8 Rehazentrum
9 University of Innsbruck

University of Innsbruck

Innsbruck, Austria

ROR https://ror.org/054pv6659
10 University of Pecs

University of Pecs

Pécs, Hungría

ROR https://ror.org/037b5pv06
11 Ruhr University Bochum

Ruhr University Bochum

Bochum, Alemania

ROR https://ror.org/04tsk2644
12 Institute of Psychiatry and Neurology

Institute of Psychiatry and Neurology

Varsovia, Polonia

ROR https://ror.org/0468k6j36
13 Bogazici University Bebek Istanbul
14 University and Teaching Hospital
15 Erasme Hospital
16 Slovak Academy of Sciences

Slovak Academy of Sciences

Bratislava, Eslovaquia

ROR https://ror.org/03h7qq074
17 Department of Clinical Genetics, Banska Bystrica
18 University of Regensburg

University of Regensburg

Ratisbona, Alemania

ROR https://ror.org/01eezs655
19 Klinikum für Psychiatrie
20 BKHTaufkirchen
21 University of Hannover

University of Hannover

Hanóver, Alemania

ROR https://ror.org/0304hq317
22 Université Paris Est, Faculté de Médecine
23 Department of Neurology, Catholic University of Sacred Heart, Gemelli University Hospital
24 Institute of Genetics and Biomedical Research-National Research Council
25 Sigmund Freud University Vienna

Sigmund Freud University Vienna

Viena, Austria

ROR https://ror.org/04hwbg047
26 University of Bern

University of Bern

Berna, Suiza

ROR https://ror.org/02k7v4d05
27 Cardiff University

Cardiff University

Cardiff, Reino Unido

ROR https://ror.org/03kk7td41
28 Hospital de Santa Maria

Hospital de Santa Maria

Lisboa, Portugal

ROR https://ror.org/05bz1tw26
29 Oslo University Hospital

Oslo University Hospital

Oslo, Noruega

ROR https://ror.org/00j9c2840
30 University of Rostock

University of Rostock

Rostock, Alemania

ROR https://ror.org/03zdwsf69
31 University of Ulm

University of Ulm

Ulm, Alemania

ROR https://ror.org/032000t02
32 University of Massachusetts Medical School

University of Massachusetts Medical School

Worcester, Estados Unidos

ROR https://ror.org/0464eyp60
33 Hospital Virgen del Camino

Hospital Virgen del Camino

Pamplona, España

ROR https://ror.org/046wwv897
34 Oslo University Hospital, Ulleval, Department of Medical Genetics
35 Division of Clinical Neurosciences, Department of Neurology, University of Turku and Turku University Hospital
36 Mutua de Terrassa

Mutua de Terrassa

Terrassa, España

ROR https://ror.org/011335j04
37 University College London

University College London

Londres, Reino Unido

ROR https://ror.org/02jx3x895
38 University of Leuven

University of Leuven

Lovaina, Bélgica

ROR https://ror.org/05f950310
39 Institut de Pathologie et de Génétique
40 Institute of Psychiatry and Neurology Department of Genetics, First Department of Neurology
41 Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague
42 Sahlgrenska University Hospital

Sahlgrenska University Hospital

Gotemburgo, Suecia

ROR https://ror.org/04vgqjj36
43 Innere Medizin 2, Klinikum Traunstein
44 Hospital Ramón y Cajal

Hospital Ramón y Cajal

Madrid, España

ROR https://ror.org/050eq1942
45 Foundation of Carlo Besta Neurological Institute
46 University Hospital Muenster

University Hospital Muenster

Münster, Alemania

ROR https://ror.org/01856cw59
47 University Medical Center Hamburg-Eppendorf

University Medical Center Hamburg-Eppendorf

Hamburgo, Alemania

ROR https://ror.org/01zgy1s35
48 The Royal Hallamshire Hospital-Sheffield Children's Hospital
49 Hôpitaux de Paris, Service de Neurologie et Faculté de Médecine Paris 12, Centre Hospitalier Universitaire Henri-Mondor
50 Bronovo Hospital

Bronovo Hospital

La Haya, Holanda

ROR https://ror.org/03r781319
51 V.G. Belinsky Penza State Pedagogic University
52 Poznan University of Medical Sciences

Poznan University of Medical Sciences

Posnania, Polonia

ROR https://ror.org/02zbb2597
53 Jagiellonian University

Jagiellonian University

Cracovia, Polonia

ROR https://ror.org/03bqmcz70
54 Catholic University of the Sacred Heart

Catholic University of the Sacred Heart

Milán, Italia

ROR https://ror.org/03h7r5v07
55 University Hospital Graz
56 Christine Verellen-Dumoulin, Institut de Pathologie et de Génétique
57 Charles University in Prague

Charles University in Prague

Praga, República Checa

ROR https://ror.org/024d6js02
58 Rehabilitation Centre Suvituuli
59 University of Oulu

University of Oulu

Oulu, Finlandia

ROR https://ror.org/03yj89h83
60 Terveystalo Healthcare Service Centre
61 Centre Hospitalier Universitaire d'Angers, Centre de référence des maladies neurogénétique
62 Hôpital Pellegrin

Hôpital Pellegrin

Burdeos, Francia

ROR https://ror.org/02x581406
63 Centre Hospitalier Regional et Universitaire de Lille

Centre Hospitalier Regional et Universitaire de Lille

Lila, Francia

ROR https://ror.org/02ppyfa04
64 CHU Nord
65 Hôpital La Timone
66 Hôpital Civil
67 Huntington Centre (NRW), St. Josef-Hospital
68 Philipp University of Marburg

Philipp University of Marburg

Marburgo, Alemania

ROR https://ror.org/01rdrb571
69 University of Bari Aldo Moro

University of Bari Aldo Moro

Bari, Italia

ROR https://ror.org/027ynra39
70 University of Bologna

University of Bologna

Bolonia, Italia

ROR https://ror.org/01111rn36
71 University of Genoa

University of Genoa

Génova, Italia

ROR https://ror.org/0107c5v14
72 Department of Neuroscience, Oftalmologia e Genetica (DiNOG)
73 Centro di Neurogenetica e Malattie Rare IRCCS Neuromed
74 Istituto Leonarda Vaccari
75 Medisch Spectrum Twente

Medisch Spectrum Twente

Enschede, Holanda

ROR https://ror.org/033xvax87
76 Polikliniek Neurologie
77 Radboud University Nijmegen Medical Centre

Radboud University Nijmegen Medical Centre

Nimega, Holanda

ROR https://ror.org/05wg1m734
78 Haukeland University Hospital

Haukeland University Hospital

Bergen, Noruega

ROR https://ror.org/03np4e098
79 NKS Olavikens HD clinic
80 St. Olavs Hospital
81 St. Adalbert Hospital, Medical University of Gdansk, Neurological and Psychiatric Nursing Department
82 Medical University of Silesia

Medical University of Silesia

Katowice, Polonia

ROR https://ror.org/005k7hp45
83 Krakowska Akademia Neurologii
84 Medical University of Warsaw, Neurology
85 Hospitais da Universidade de Coimbra

Hospitais da Universidade de Coimbra

Coímbra, Portugal

ROR https://ror.org/04032fz76
86 Hospital de São João

Hospital de São João

Oporto, Portugal

ROR https://ror.org/04qsnc772
87 Hospital Infanta Cristina

Hospital Infanta Cristina

Parla, España

ROR https://ror.org/05txkk980
88 Hospital Universitario San Cecilio

Hospital Universitario San Cecilio

Granada, España
89 Complejo Asistencial Universitario de Burgos

Complejo Asistencial Universitario de Burgos

Burgos, España

ROR https://ror.org/01j5v0d02
90 Hospital de Fuenlabrada

Hospital de Fuenlabrada

Fuenlabrada, España

ROR https://ror.org/04scbtr44
91 Hospital Clínico San Carlos de Madrid

Hospital Clínico San Carlos de Madrid

Madrid, España

ROR https://ror.org/04d0ybj29
92 Fundación Jiménez Díaz

Fundación Jiménez Díaz

Madrid, España

ROR https://ror.org/049nvyb15
93 Hospital Virgen de la Arrixaca

Hospital Virgen de la Arrixaca

Murcia, España

ROR https://ror.org/058thx797
94 University Hospital Mú tua de Terrassa
95 Hospital Universitari de Bellvitge

Hospital Universitari de Bellvitge

l'Hospitalet de Llobregat, España

ROR https://ror.org/00epner96
96 Hospital Mare de Deu de La Merced
97 Hospital Universitario Central de Asturias

Hospital Universitario Central de Asturias

Oviedo, España

ROR https://ror.org/03v85ar63
98 Hospital Universitario Son Espases

Hospital Universitario Son Espases

Palma, España

ROR https://ror.org/05jmd4043
99 Hospital Universitario Virgen Macarena

Hospital Universitario Virgen Macarena

Sevilla, España

ROR https://ror.org/016p83279
100 Hospital Universitario Virgen del Rocío

Hospital Universitario Virgen del Rocío

Sevilla, España

ROR https://ror.org/04vfhnm78
101 Umeå University Hospital
102 Karolinska University Hospital

Karolinska University Hospital

Estocolmo, Suecia

ROR https://ror.org/00m8d6786
103 Swiss HD Zentrum
104 University of Aberdeen

University of Aberdeen

Aberdeen, Reino Unido

ROR https://ror.org/016476m91
105 The Barberry Centre, Department of Psychiatry
106 Cambridge Centre for Brain Repair, Forvie Site
107 Western General Hospital, SE Scotland Genetic Service
108 Scottish Huntington's Association Whyteman's Brae Hospital
109 Gloucestershire Royal Hospital, Department of Neurology
110 Castle Hill Hospital

Castle Hill Hospital

Cottingham, Reino Unido

ROR https://ror.org/042asnw05
111 Chapel Allerton Hospital, Department of Clinical Genetics
112 National Health Service

National Health Service

Londres, Reino Unido

ROR https://ror.org/02wnqcb97
113 Guy's Hospital

Guy's Hospital

Londres, Reino Unido

ROR https://ror.org/04r33pf22
114 St Georges Hospital

St Georges Hospital

Morpeth, Reino Unido

ROR https://ror.org/0547wea53
115 Newcastle upon Tyne Hospitals NHS Foundation Trust

Newcastle upon Tyne Hospitals NHS Foundation Trust

Newcastle-upon-Tyne, Reino Unido

ROR https://ror.org/05p40t847
116 University of Oxford

University of Oxford

Oxford, Reino Unido

ROR https://ror.org/052gg0110
117 Mount Gould Hospital, Plymouth Huntington Disease Service