Long COVID Symptomatology and Associated Factors in Primary Care Patients: The EPICOVID-AP21 Study

  1. Romero-Rodríguez, Esperanza
  2. Perula-de-Torres, Luis Ángel
  3. González-Lama, Jesús
  4. Castro-Jiménez, Rafael Ángel
  5. Jiménez-García, Celia
  6. Priego-Pérez, Carmen
  7. Vélez-Santamaría, Rodrigo
  8. Simón-Vicente, Lucía
  9. González-Santos, Josefa
  10. González-Bernal, Jerónimo J.
  1. 1 Universidad de Córdoba
    info

    Universidad de Córdoba

    Córdoba, España

    ROR https://ror.org/05yc77b46

  2. 2 Multiprofessional Family and Community Care Teaching Unit of Córdoba
  3. 3 Multiprofessional Teaching Unit for Family and Community Care, Córdoba and Guadalquivir Health District, 14011 Córdoba, Spain
  4. 4 Carlos Castilla del Pino Clinical Management Unit, Córdoba
  5. 5 “Matrona Antonia Mesa Fernández” Health Center, Cabra Clinical Management Unit, AGS South of Córdoba
  6. 6 Hospital Universitario Reina Sofia
    info

    Hospital Universitario Reina Sofia

    Córdoba, España

    ROR https://ror.org/02vtd2q19

  7. 7 Department of Health Sciences, University of Burgos
Revista:
Healthcare

ISSN: 2227-9032

Año de publicación: 2023

Volumen: 11

Número: 2

Páginas: 218-230

Tipo: Artículo

DOI: 10.3390/HEALTHCARE11020218 GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Healthcare

Resumen

Persistent COVID-19 condition includes a wide variety of symptoms and health problems of indeterminate duration. The present study examined the sociodemographic and clinical characteristics of the population with Long COVID seen in Primary Care using a questionnaire based on the existing scientific literature. It was an observational and descriptive study of the characteristics of the Spanish population with Long COVID over 14 years of age. The responses were analysed by means of a descriptive analysis of the variables recorded, in addition to a bivariate analysis to determine the existence of a relationship between persistent COVID-19 and variables such as gender, age, vaccination status or concomitant pathology. The results obtained clearly describe the sociodemographic characteristics of the population, highlighting the predominance of female gender and the prevalence of tiredness and fatigue. Furthermore, relevant information was obtained on the differences in symptomatology according to gender, age, previous pathologies and alterations derived from infection and/or vaccination. These data are important for better detection, diagnosis and treatment of Long COVID and the improvement of the quality of life of this population.

Referencias bibliográficas

  • Ministerio de Sanidad (2021, December 31). Minist Sanid 2022. Available online: https://www.sanidad.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov/situacionActual.htm.
  • Consilium (2021, September 23). COVID-19: Respuesta de la UE en el Ámbito de la Salud Pública. Available online: https://www.consilium.europa.eu/es/policies/coronavirus/covid-19-public-health/.
  • (2021), Aten. Primaria, 53, pp. 101956, 10.1016/j.aprim.2020.12.001
  • (2021), Med. Clin., 156, pp. 595
  • Guan, (2020), N. Engl. J. Med., 382, pp. 1708, 10.1056/NEJMoa2002032
  • Wu, (2020), JAMA, 323, pp. 1239, 10.1001/jama.2020.2648
  • Centros Para el Control y la Prevención de Enfermedades (2021, September 23). Afecciones Persistentes al COVID-19 y Afecciones Posteriores al COVID-19 2022, Available online: https://espanol.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html.
  • Soriano, J., Murthy, S., Marshall, J., Relan, P., and Diaz, J. (2021). A Clinical Case Definition of Post COVID-19 Condition by a Delphi Consensus, WHO.
  • The PHOSP-COVID Collaborative Group (2022). Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: A prospective observational study. Lancet. Respir. Med., 10, 761–775.
  • (2021, September 28). Guía Clínica Para la Atención al Paciente LONG COVID/COVID Persistente 2021. Available online: https://www.semg.es/index.php/consensos-guias-y-protocolos/363-guia-clinica-para-la-atencion-al-paciente-long-covid-covid-persistente.
  • Davis, (2021), eClinicalMedicine, 38, pp. 101019, 10.1016/j.eclinm.2021.101019
  • Hirschtick, (2021), Clin. Infect. Dis., 73, pp. 2055, 10.1093/cid/ciab408
  • Sudre, (2021), Nat. Med., 27, pp. 626, 10.1038/s41591-021-01292-y
  • Bliddal, (2021), Sci. Rep., 11, pp. 13153, 10.1038/s41598-021-92045-x
  • Chen, (2022), J. Infect. Dis., 226, pp. 1593, 10.1093/infdis/jiac136
  • Daitch, (2022), Int. J. Infect. Dis., 125, pp. 287, 10.1016/j.ijid.2022.09.035
  • Fernández-De-las-peñas, C., Martín-Guerrero, J.D., Pellicer-Valero, Ó.J., Navarro-Pardo, E., Gómez-Mayordomo, V., Cuadrado, M.L., Arias-Navalón, J.A., Cigarán-Méndez, M., Hernández-Barrera, V., and Arendt-Nielsen, L. (2022). Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related-Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study. J. Clin. Med., 11.
  • Yelin, D., Margalit, I., Nehme, M., Bordas-Martínez, J., Pistelli, F., Yahav, D., Guessous, I., Durà-Miralles, X., Carrozzi, L., and Shapira-Lichter, I. (2022). Patterns of Long COVID Symptoms: A Multi-Center Cross Sectional Study. J. Clin. Med., 11.
  • Crespo, (2022), Sci. Rep., 12, pp. 3369, 10.1038/s41598-022-07414-x
  • Guijarro, (2022), Int. J. Infect. Dis., 116, pp. 241, 10.1016/j.ijid.2022.01.007
  • Organización Mundial de la Salud (2021, October 01). Enfermedad Por Coronavirus (COVID-19): Afección Posterior a la COVID-19 2021. Available online: https://www.who.int/es/news-room/questions-and-answers/item/coronavirus-disease-(covid-19)-post-covid-19-condition.
  • Scientific Advisory Group (Alberta Health Services, Physical distancing works, 2021). COVID-19 Scientific Advisory Group Rapid Evidence Report. Updat. Rev. Prolong. symptoms after acute COVID-19 Infect, Alberta Health Services, Physical distancing works.
  • Tleyjeh, (2022), J. Infect. Public Health, 15, pp. 21, 10.1016/j.jiph.2021.11.016
  • Ministerio de Sanidad (2021, September 23). Manejo en Atención Primaria y Domiciliaria del COVID-19 2020. Available online: https://www.sanidad.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov/documentos/Manejo_primaria.pdf.
  • Perelman, (2021), Sci. Rep., 11, pp. 16144, 10.1038/s41598-021-95565-8
  • Akbari, (2021), Iran. J. Med. Sci., 46, pp. 428
  • Salari, (2022), Biopsychosoc. Med., 16, pp. 21, 10.1186/s13030-022-00250-5
  • Calabria, (2022), J. Neurol., 269, pp. 3990, 10.1007/s00415-022-11141-8
  • Robbins, (2021), Clin. Med., 21, pp. E629, 10.7861/clinmed.2021-0462
  • Tana, (2022), J. Headache Pain, 23, pp. 93, 10.1186/s10194-022-01450-8
  • Rivera-Izquierdo, M., Láinez-Ramos-Bossini, A.J., de Alba, I.G.F., Ortiz-González-Serna, R., Serrano-Ortiz, Á., Fernández-Martínez, N.F., Ruiz-Montero, R., and Cervilla, J.A. (2022). Long COVID 12 months after discharge: Persistent symptoms in patients hospitalised due to COVID-19 and patients hospitalised due to other causes-a multicentre cohort study. BMC Med., 20.
  • Sylvester, (2022), Curr. Med. Res. Opin., 38, pp. 1391, 10.1080/03007995.2022.2081454
  • Pinzon, (2022), J. Infect. Public Health, 15, pp. 856, 10.1016/j.jiph.2022.06.013
  • Stefanou, M.-I., Palaiodimou, L., Bakola, E., Smyrnis, N., Papadopoulou, M., Paraskevas, G.P., Rizos, E., Boutati, E., Grigoriadis, N., and Krogias, C. (2022). Neurological manifestations of long-COVID syndrome: A narrative review. Ther. Adv. Chronic Dis., 13.
  • Baig, (2021), CNS Neurosci. Ther., 27, pp. 1433, 10.1111/cns.13737
  • Aiyegbusi, (2021), J. R. Soc. Med., 114, pp. 428, 10.1177/01410768211032850
  • Yong, (2021), Infect. Dis., 53, pp. 737, 10.1080/23744235.2021.1924397
  • Whitaker, (2022), Nat. Commun., 13, pp. 1957, 10.1038/s41467-022-29521-z
  • Wu, (2022), Res. Sq., 12, pp. 11647
  • Wang, (2022), Front. Cell. Infect. Microbiol., 12, pp. 861703, 10.3389/fcimb.2022.861703
  • Gao, P., Liu, J., and Liu, M. (2022). Effect of COVID-19 Vaccines on Reducing the Risk of Long COVID in the Real World: A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health, 19.
  • Ledford, (2021), Nature, 599, pp. 546, 10.1038/d41586-021-03495-2
  • Vogel, (2022), Science, 375, pp. 364, 10.1126/science.ada0536
  • Notarte, (2022), eClinicalMedicine, 53, pp. 101624, 10.1016/j.eclinm.2022.101624
  • Bai, (2022), Clin. Microbiol. Infect., 28, pp. 611.e9, 10.1016/j.cmi.2021.11.002