Effects of dietary supplementation with epigallocatechin-3-gallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: randomised, double-blind, placebo-controlled clinical trial
- Mielgo-Ayuso, Juan 1
- Barrenechea, Lurdes 1
- Alcorta, Pilar 1
- Larrarte, Eider 2
- Margareto, Javier 2
- Labayen, Idoia 1
-
1
Universidad del País Vasco/Euskal Herriko Unibertsitatea
info
Universidad del País Vasco/Euskal Herriko Unibertsitatea
Lejona, España
- 2 Biomedical Research Area, Tecnalia, Miñano
ISSN: 0007-1145, 1475-2662
Año de publicación: 2013
Volumen: 111
Número: 7
Páginas: 1263-1271
Tipo: Artículo
Otras publicaciones en: British Journal of Nutrition
Resumen
The aim of the present study was to examine the effects of green tea epigallocatechin-3-gallate (EGCG) on changes in body composition, energy and substrate metabolism, cardiometabolic risk factors and liver function enzymes after an energy-restricted diet intervention in obese women. In the present randomised, double-blind, placebo-controlled study, eighty-three obese (30 kg/m2>BMI < 40 kg/m2) pre-menopausal women consumed 300 mg/d of EGCG or placebo (lactose). We measured body weight and adiposity (dual-energy X-ray absorptiometry), energy expenditure and fat oxidation rates (indirect calorimetry), blood lipid levels (TAG, total cholesterol, LDL-cholesterol and HDL-cholesterol), insulin resistance, C-reactive protein and liver function markers (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, γ-glutamyltransferase, urea, bilirubin and 2-keto[1-13C]isocaproate oxidation) before and after the intervention in the EGCG and control groups. We did not find any significant difference in the changes in body weight ( − 0·3 kg, 95 % CI − 5·0, 4·3), fat mass ( − 0·7 kg, 95 % CI − 3·5, 2·1), energy (0·3 kJ/kg per d, 95 % CI − 3·1, 2·7) and fat ( − 0·1 g/min, 95 % CI − 0·03, 0·01) metabolism, homeostasis assessment model for insulin resistance (0·2, 95 % CI − 0·2, 0·7), total cholesterol ( − 0·21 mmol/l, 95 % CI − 0·55, 0·13), LDL-cholesterol ( − 0·15 mmol/l, 95 % CI − 0·50, 0·20), TAG ( − 0·14 mmol/l, 95 % CI − 0·56, 0·29) and liver function markers between the EGCG and control groups. In conclusion, the present results suggest that dietary supplementation with 300 mg/d of EGCG for 12 weeks did not enhance energy-restricted diet-induced adiposity reductions, and did not improve weight-loss-induced changes in cardiometabolic risk factors in obese Caucasian women. The intake of 300 mg/d of EGCG for 12 weeks did not cause any adverse effect on liver function biomarkers.
Referencias bibliográficas
- 10.1371/journal.pone.0023759
- 10.1146/annurev.pharmtox.42.082101.154309
- 10.2165/00002018-200831060-00003
- 10.1111/j.1365-2362.2010.02331.x
- 10.1177/0145721706290437
- 10.2337/diacare.27.6.1487
- 10.1038/oby.2007.529
- 10.1017/S0007114511005095
- 10.1038/sj.ejcn.1602806
- 10.1079/BJN20041061
- 10.1007/s12011-012-9448-z
- 10.1007/s00228-008-0610-7
- 10.1017/S0007114509991218
- 10.1089/acm.2009.0188
- 10.1038/oby.2007.354
- 10.1038/ejcn.2010.47
- 10.3945/ajcn.2009.28157
- 10.1016/j.clnu.2003.10.004
- 10.1016/j.diabres.2005.08.001
- 10.1079/BJN20051502
- 10.1053/meta.2003.50075
- 10.1038/sj.ejcn.1601309
- Bose, (2008), J Nutr, 138, pp. 1677, 10.1093/jn/138.9.1677
- 10.1016/j.jnutbio.2010.06.006
- 10.1016/j.clnu.2008.03.007
- Bantle, (2008), Diabetes Care, 31, pp. S61, 10.2337/dc08-S061
- 10.1016/j.numecd.2011.03.003
- 10.3945/jn.108.096412
- 10.1038/ijo.2009.299
- 10.1016/j.phrs.2010.12.013
- 10.1080/10408399709527797
- 10.1016/j.physbeh.2010.02.005
- 10.1038/oby.2009.256
- Yellapu, (2011), Can J Gastroenterol, 25, pp. 157, 10.1155/2011/174978
- 10.1038/ijo.2009.135
- 10.1016/j.jada.2007.05.009
- 10.1007/s003940050057
- 10.1017/S0007114509371779
- 10.1017/S0007114508047727
- 10.1038/oby.2007.176
- 10.1079/BJN20051580
- 10.1016/j.jada.2006.02.009
- Dulloo, (1999), Am J Clin Nutr, 70, pp. 1040, 10.1093/ajcn/70.6.1040
- 10.1111/j.1467-789X.2005.00170.x
- 10.1016/j.jsgi.2005.10.006
Los documentos del portal se actualizan diariamente. Esta fecha hace referencia a la actualización de la información relacionada con la estructura del portal (personas, grupos de investigación, unidades organizativas, proyectos...).