Desarrollo de nuevos fármacos para el tratamiento de cáncer de pulmón de células escamosas
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Universidad de Burgos
info
- Joaquín Antonio Pacheco Bonrostro (dir.)
- José Luis Cuesta Gómez (coord.)
Argitaletxea: Servicio de Publicaciones e Imagen Institucional ; Universidad de Burgos
ISBN: 978-84-16283-30-9, 84-16283-30-3
Argitalpen urtea: 2016
Orrialdeak: 291-297
Biltzarra: Jornadas de Doctorandos de la Universidad de Burgos (3. 2016. Burgos)
Mota: Biltzar ekarpena
Laburpena
Lung squamous cell carcinoma is one of the most extended types of lung cancer, and nowadays its treatment doesn’t show good clinical results. The aim of this project is to develop new drugs for treatment this type of cancer. Several studies have concluded that Survivin, a protein involved in cell division processes and apoptosis, can be used as novel therapeutic target for this cancer. It is known that the activity of Survivin is naturally inhibited by binding with the pro-apoptotic mitochondrial protein Smac/Diablo. Based on this idea new Smac/Diablo mimetics have been designed and synthesized in order to validate Survivin as a novel therapeutic target and development of new drugs for this disease.
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