Desarrollo de nuevos fármacos para el tratamiento de cáncer de pulmón de células escamosas

  1. Sandra Díaz Cabrera 1
  2. Roberto Quesada Pato 1
  3. María García Valverde 1
  1. 1 Universidad de Burgos
    info

    Universidad de Burgos

    Burgos, España

    ROR https://ror.org/049da5t36

Libro:
III Jornadas de Doctorandos de la Universidad de Burgos: Universidad de Burgos, 15 y 16 de diciembre de 2016
  1. Joaquín Antonio Pacheco Bonrostro (dir.)
  2. José Luis Cuesta Gómez (coord.)

Editorial: Servicio de Publicaciones e Imagen Institucional ; Universidad de Burgos

ISBN: 978-84-16283-30-9,  84-16283-30-3

Ano de publicación: 2016

Páxinas: 291-297

Congreso: Jornadas de Doctorandos de la Universidad de Burgos (3. 2016. Burgos)

Tipo: Achega congreso

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Resumo

Lung squamous cell carcinoma is one of the most extended types of lung cancer, and nowadays its treatment doesn’t show good clinical results. The aim of this project is to develop new drugs for treatment this type of cancer. Several studies have concluded that Survivin, a protein involved in cell division processes and apoptosis, can be used as novel therapeutic target for this cancer. It is known that the activity of Survivin is naturally inhibited by binding with the pro-apoptotic mitochondrial protein Smac/Diablo. Based on this idea new Smac/Diablo mimetics have been designed and synthesized in order to validate Survivin as a novel therapeutic target and development of new drugs for this disease.

Fonte de datos: Dialnet