Niveles de tiorredoxina plasmática en individuos sanos adultos

  1. Pilar Muñiz 1
  2. Mónica Cavia 1
  3. Celia Guerrero 1
  4. Silvia Ruiz-Crespo 1
  5. Marta Herreros 1
  6. María Jesús Coma 1
  1. 1 Unidad de Investigación del Hospital General Yagüe. Complejo Asistencial Universitario de Burgos.
Journal:
Revista Electrónica de Biomedicina

ISSN: 1697-090X

Year of publication: 2010

Issue: 2

Pages: 12-17

Type: Article

DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Revista Electrónica de Biomedicina

Abstract

OBJECTIVE: Evaluation of normal plasma levels of thioredoxin in a healthy adult population. MATERIAL AND METHODS: The blood were collected from 49 healthy adult persons, whose health was assumed because the persons are regular blood donors. The participation was voluntary and the informed written consent was obtained for all persons. The assay of thioredoxin (Trx) was carried out in the Research Unit of Complejo Asistencial Universitario de Burgos. Furthermore, we searched Medline for scientific studies after 2000 year, in which have included a control group of healthy adults. RESULTS: The results showed a large variability between individuals, in the thioredoxin levels in healthy blood donors. The average obtained was of 31.37±10.87 ng/ml (12.25 - 50.77 ng/ml) and with a percentage of variation (CV) of 34.6% and interquartile range of 22.77 to 38.88 ng/ml. A total of seven series of thioredoxin values for healthy subjects were obtained of scientific studies and were used as controls for case-control studies. Most were series very short, which showed a wide variation in their average.

Bibliographic References

  • Nakamura H, Nakamura K, Yodoi J. Redox regulation of cellular activation. Annu Rev Immunol. 1997;15:351-369.
  • Sen CK. Redox signaling and the emerging therapeutic potential of thiol antioxidants. Biochem Pharmacol. 1998;55:1747-1758.
  • Soderberg A, Sahaf B, Rosen A. Thioredoxin reductase, a redox-active selenoprotein, is secreted by normal and neoplastic cells: presence in human plasma. Cancer Res. 2000; 60: 2281-2289
  • Angelini G, Gardella S, Ardy M, Ciriolo MR, Filomeni G, Di Trapani G, Clarke F, Sitia R, Rubartelli A.Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation. Proc Natl Acad Sci USA. 2002; 99: 1491-1496.
  • Kogaki H, Fujiwara Y, Yoshiki A, Kitajima S, Tanimoto T, Mitsui A, Shimamura T, Hamuro J, Ashihara Y. Sensitive enzyme-linked immunosorbent assay for adult T-cell leukemia-derived factor and normal value measurement. J Clin Lab Anal. 1996; 10: 257-26
  • Nakamura H, De Rosa S, Roederer M, Anderson MT, Dubs JG, Yodoi J, Holmgren A, Herzenberg LA, Herzenberg LA. Elevation of plasma thioredoxin levels in HIV-infected individuals. Int Immunol. 1996; 8, 603-611.
  • Nakamura H, Bai J, Nishinaka Y, Ueda S, Sasada T, Ohshio G, Imamura M, Takabayashi A, Yamaoka Y, Yodoi J. Expression of thioredoxin and glutaredoxin, redox-regulating proteins, in pancreatic cancer. Cancer Detect Prev. 2000; 24: 53-60.
  • Nakamura H, Vaage J, Valen G, Padilla CA, Björnstedt M, Holmgren A. Measurements of plasma glutaredoxin and thioredoxin in healthy volunteers and during open-heart surgery. Free Radic Biol Med. 1998; 24: 1176-1186.
  • Jikimoto T, Nishikubo Y, Koshiba M, Kanagawa S, Morinobu S, Morinobu A, Saura R, Mizuno K, Kondo S, Toyokuni S, Nakamura H, Yodoi J, Kumagai S. Thioredoxin as a biomarker for oxidative stress in patients with rheumatoid arthritis. Mol Immunol. 2002; 38: 765-772.
  • Kishimoto C, Shioji K, Nakamura H, Nakayama Y, Yodoi J, Sasayama S. Serum thioredoxin (TRX) levels in patients with heart failure. Jpn Circ J. 2001; 65(6):491-4.
  • Marumoto M, Suzuki S, Hosono A, Arakawa K, Shibata K, Fuku M, Goto C, Tokudome Y, Hoshino H, Imaeda N, Kobayashi M, Yodoi J, Tokudome S. Changes in thioredoxin concentrations: an observation in an ultra-marathon race. Environ Health Prev Med. 2010; 15(3) 129-134
  • Lemarechal H, Allanore Y, Chenevier-Gobeaux C, Ekindjian OG, Kahan A, Borderie D. High redox thioredoxin but low thioredoxin reductase activities in the serum of patients with rheumatoid arthritis. Clin Chim Acta. 2006; 367: 156-161.
  • Jekell A, Hossaina A, Alehagenb U, Dahlströmb U, Roséna A. Elevated circulating levels of thioredoxin and stress in chronic heart failure. European Journal of Heart Failure 2004; 6: 883-890
  • Kato A, Odamaki M, Nakamura H, Yodoi J, Hishida A. Elevation of blood thioredoxin in hemodialysis patients with hepatitis C virus infection. Kidney International 2003; 63: 2262-2268
  • Baker AF, Dragovich T, Tate WR, Ramanathan RK, Roe D, Hsu CH, Kirkpatrick DL, Powis G.J The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma. Lab Clin Med. 2006 147(2):83-90.
  • Sumida Y, Nakashima T, Yoh T, Nakajima Y, Ishikawa H, Mitsuyoshi H, Sakamoto Y, Okanoue T, Kashima K, Nakamura H, Yodoi J. Serum thioredoxin levels as an indicator of oxidative stress in patients with hepatitis C virus infection. J Hepatol. 2000; 33: 616-622.
  • Sumida Y, Nakashima T, Yoh T, Furutani M, Hirohama A, Kakisaka Y, Nakajima Y, Ishikawa H, Mitsuyoshi H, Okanoue T, Kashima K, Nakamura H, Yodoi J. Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease. J Hepatol. 2003; 38: 32-38.
  • Calliste ME, Burke-Gaffney A, Quinlan G-J, Nicholson AG, Florio R, Nakamura H, Yodoi H, Evans TW. Extracellular thioredoxin levels are increased in patients with acute lung injury. Thorax 2006;61:521-527
  • Leaver SK, MacCallum NS, Pingle V, Hacking MB, Quinlan GJ, Evans TW, Burke-Gaffney A. Increased plasma thioredoxin levels in patients with sepsis: positive association with macrophage migration inhibitory factor. Intensive Care Med. 2010; 36: 336-341.
  • Nakashima T, Sumida Y, Furutani M, Hirohama A, Okita M, Mitsuyoshi H, Itoh Y, Okanoue T. Elevation of serum thioredoxin levels in patients with nonalcoholic steatohepatitis. Hepatol Res. 2005; 33:135-137.
Data source: Dialnet